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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
22.73
Human Site:
S291
Identified Species:
35.71
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
S291
S
E
S
P
S
G
F
S
K
H
I
Q
S
N
L
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
S291
S
E
S
P
S
G
F
S
K
H
I
Q
S
N
L
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
S291
S
E
S
P
S
G
F
S
K
H
I
Q
S
N
L
Dog
Lupus familis
XP_852191
460
52810
S275
S
E
S
P
S
G
F
S
K
H
I
Q
S
N
L
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
S291
S
E
S
S
S
G
F
S
K
H
I
H
S
N
L
Rat
Rattus norvegicus
Q91ZN7
476
54410
S291
S
E
S
S
S
G
F
S
K
H
I
H
S
N
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
G291
A
D
S
P
G
G
F
G
K
H
I
R
S
S
L
Chicken
Gallus gallus
Q8AYC9
476
53830
P291
T
E
S
P
G
A
L
P
K
H
I
R
S
D
T
Frog
Xenopus laevis
Q6DE87
474
53957
C290
S
S
D
S
S
V
L
C
K
Q
I
R
S
D
I
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
L242
I
Q
R
A
D
S
E
L
R
R
K
N
S
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
S303
A
A
A
L
E
I
C
S
P
K
A
K
R
Q
R
Honey Bee
Apis mellifera
XP_623436
467
53927
I289
E
T
D
S
R
Q
I
I
E
D
E
N
L
T
R
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
I311
A
R
N
N
D
E
N
I
T
C
T
Q
Q
A
E
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
N291
M
K
R
V
C
T
G
N
D
L
S
P
L
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
N252
I
V
R
I
L
D
P
N
P
M
T
R
I
T
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
60
46.6
33.3
6.6
N.A.
6.6
0
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
86.6
66.6
53.3
26.6
N.A.
26.6
6.6
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
7
7
7
0
7
0
0
0
0
7
0
0
14
7
% A
% Cys:
0
0
0
0
7
0
7
7
0
7
0
0
0
0
0
% C
% Asp:
0
7
14
0
14
7
0
0
7
7
0
0
0
20
7
% D
% Glu:
7
47
0
0
7
7
7
0
7
0
7
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
14
47
7
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
54
0
14
0
0
0
% H
% Ile:
14
0
0
7
0
7
7
14
0
0
60
0
7
0
14
% I
% Lys:
0
7
0
0
0
0
0
0
60
7
7
7
0
0
0
% K
% Leu:
0
0
0
7
7
0
14
7
0
7
0
0
14
0
47
% L
% Met:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
7
7
0
0
7
14
0
0
0
14
0
40
0
% N
% Pro:
0
0
0
40
0
0
7
7
14
0
0
7
0
0
0
% P
% Gln:
0
7
0
0
0
7
0
0
0
7
0
34
7
7
0
% Q
% Arg:
0
7
20
0
7
0
0
0
7
7
0
27
7
0
14
% R
% Ser:
47
7
54
27
47
7
0
47
0
0
7
0
67
7
0
% S
% Thr:
7
7
0
0
0
7
0
0
7
0
14
0
0
14
7
% T
% Val:
0
7
0
7
0
7
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _